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ACTN2 has not been detected as a mutational cancer driver

ACTN2
Ensembl id ENSG00000077522
Mutated samples
Coding Sequence 136 (2.0%)
Protein Affecting 95 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ACTN2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 23 19 4.86
Cutaneous melanoma No 28 17 4.61
Stomach adenocarcinoma No 14 10 6.21
Breast carcinoma No 13 9 0.78
Lung squamous cell carcinoma No 12 9 5.17
Colorectal adenocarcinoma No 9 7 3.06
Head and neck squamous cell carcinoma No 9 6 1.60
Small cell lung carcinoma No 5 5 7.25
Uterine corpus endometrioid carcinoma No 5 4 1.74
Renal clear cell carcinoma No 4 3 0.72
Serous ovarian adenocarcinoma No 4 3 0.95
Neuroblastoma No 2 2 0.95
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Bladder carcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence