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ACTG2 is detected as a mutational cancer driver in 1 cancer type: Lung squamous cell carcinoma and in the PAN-cancer analysis

ACTG2
Ensembl id ENSG00000163017
Mutated samples
Coding Sequence 41 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
LUSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ACTG2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 6 6 3.45
Cutaneous melanoma Yes 13 6 1.63
Lung adenocarcinoma Yes 7 5 1.28
Stomach adenocarcinoma Yes 3 3 1.86
Head and neck squamous cell carcinoma No 4 4 1.07
Breast carcinoma No 2 2 0.17
Glioblastoma multiforme No 2 2 0.53
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence