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ABL2 is detected as a mutational cancer driver in 1 cancer type: Lung squamous cell carcinoma

ABL2
Ensembl id ENSG00000143322
Mutated samples
Coding Sequence 101 (1.5%)
Protein Affecting 67 (1.0%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
LUSC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ABL2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 5 5 2.87
Cutaneous melanoma No 25 15 4.07
Breast carcinoma No 9 8 0.70
Lung adenocarcinoma No 11 7 1.79
Head and neck squamous cell carcinoma No 8 6 1.60
Small cell lung carcinoma No 5 5 7.25
Uterine corpus endometrioid carcinoma No 7 4 1.74
Colorectal adenocarcinoma No 4 4 1.75
Glioblastoma multiforme No 5 3 0.79
Renal clear cell carcinoma No 2 2 0.48
Stomach adenocarcinoma No 4 2 1.24
Esophageal carcinoma No 3 2 1.37
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Serous ovarian adenocarcinoma No 2 1 0.32
Hepatocarcinoma No 3 0 0.00
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence