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ABCG8 has not been detected as a mutational cancer driver

ABCG8
Ensembl id ENSG00000143921
Mutated samples
Coding Sequence 85 (1.3%)
Protein Affecting 58 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ABCG8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 16 4.34
Lung squamous cell carcinoma No 9 7 4.02
Head and neck squamous cell carcinoma No 8 6 1.60
Lung adenocarcinoma No 11 5 1.28
Breast carcinoma No 4 4 0.35
Small cell lung carcinoma No 4 4 5.80
Uterine corpus endometrioid carcinoma No 4 3 1.30
Stomach adenocarcinoma No 3 3 1.86
Renal clear cell carcinoma No 3 2 0.48
Thyroid carcinoma No 3 2 0.62
Multiple myeloma No 2 2 2.90
Acute myeloid leukemia No 1 1 0.51
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Bladder carcinoma No 2 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence