Top
ABCB11 has not been detected as a mutational cancer driver

ABCB11
Ensembl id ENSG00000073734
Mutated samples
Coding Sequence 107 (1.6%)
Protein Affecting 81 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ABCB11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 47 35 9.49
Lung adenocarcinoma No 17 13 3.32
Breast carcinoma No 9 7 0.61
Lung squamous cell carcinoma No 6 5 2.87
Head and neck squamous cell carcinoma No 5 4 1.07
Serous ovarian adenocarcinoma No 3 3 0.95
Thyroid carcinoma No 2 2 0.62
Neuroblastoma No 2 2 0.95
Stomach adenocarcinoma No 3 2 1.24
Glioblastoma multiforme No 4 2 0.53
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 2 1 0.43
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence