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ABCA4 has not been detected as a mutational cancer driver

ABCA4
Ensembl id ENSG00000198691
Mutated samples
Coding Sequence 183 (2.7%)
Protein Affecting 135 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ABCA4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 63 46 12.47
Lung squamous cell carcinoma No 16 12 6.90
Head and neck squamous cell carcinoma No 15 12 3.20
Lung adenocarcinoma No 10 10 2.56
Breast carcinoma No 13 10 0.87
Uterine corpus endometrioid carcinoma No 8 6 2.61
Stomach adenocarcinoma No 9 5 3.11
Glioblastoma multiforme No 8 5 1.32
Serous ovarian adenocarcinoma No 4 4 1.27
Small cell lung carcinoma No 4 4 5.80
Bladder carcinoma No 4 3 3.06
Renal clear cell carcinoma No 4 3 0.72
Prostate adenocarcinoma No 3 2 0.82
Medulloblastoma No 2 2 0.95
Non small cell lung carcinoma No 4 2 6.45
Chronic lymphocytic leukemia No 2 2 0.69
Esophageal carcinoma No 2 2 1.37
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Lower grade glioma No 2 1 0.59
Colorectal adenocarcinoma No 5 1 0.44
Diffuse B cell lymphoma No 2 1 4.35
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence