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ABCA12 has not been detected as a mutational cancer driver

ABCA12
Ensembl id ENSG00000144452
Mutated samples
Coding Sequence 243 (3.6%)
Protein Affecting 192 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ABCA12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 73 58 15.72
Lung adenocarcinoma No 23 20 5.12
Stomach adenocarcinoma No 21 15 9.32
Colorectal adenocarcinoma No 13 12 5.24
Head and neck squamous cell carcinoma No 13 11 2.93
Uterine corpus endometrioid carcinoma No 13 10 4.35
Breast carcinoma No 10 8 0.70
Esophageal carcinoma No 10 8 5.48
Renal clear cell carcinoma No 9 7 1.68
Serous ovarian adenocarcinoma No 7 7 2.22
Lung squamous cell carcinoma No 10 6 3.45
Small cell lung carcinoma No 7 6 8.70
Prostate adenocarcinoma No 3 3 1.23
Hepatocarcinoma No 7 3 3.33
Bladder carcinoma No 3 3 3.06
Pancreas adenocarcinoma No 3 3 1.40
Neuroblastoma No 2 2 0.95
Non small cell lung carcinoma No 2 2 6.45
Chronic lymphocytic leukemia No 4 2 0.69
Diffuse B cell lymphoma No 2 2 8.70
Glioblastoma multiforme No 3 2 0.53
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Multiple myeloma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence