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TP53 is detected as a mutational cancer driver in Non-Small Cell Lung Cancer

TP53 reports in Non-Small Cell Lung Cancer (NSCLC)

Cancer type details
Non-Small Cell Lung Cancer
Cohorts 2
Samples 564
Mutations 22,065,649
Driver genes 48
Gene details
TP53
Ensembl ID ENSG00000141510
Transcript ID ENST00000269305
Protein ID ENSP00000269305
Cohorts where is driver 2
Mutated samples 301
Mutated samples (%) 53.37
Mutations 381
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence