IntOGen - MTOR gene cancer mutations in UCEC

MTOR is detected as a mutational cancer driver in Endometrial Carcinoma

MTOR reports in Endometrial Carcinoma (UCEC)

Methods
Mutation distribution

Cancer type details

Endometrial Carcinoma
Cohorts 4 Samples 691 Mutations 3,631,382 Driver genes 69

Gene details

MTOR
Ensembl ID ENSG00000198793 Transcript ID ENST00000361445 Protein ID ENSP00000354558
Cohorts where is driver 2 Mutated samples 32 Mutated samples (%) 4.63 Mutations 43
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence