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MLH1 has not been detected as a mutational cancer driver in this cancer type

Prostate adenocarcinoma
Projects 1
243 Samples
Coding sequence mutations (CSMs)
in driver genes 372
in all genes 19342
Protein affecting mutations (PAMs)
in driver genes 326
in all genes 9006
MLH1
Ensembl id ENSG00000076242
Mutated samples
Coding Sequence 2 (0.8%)
Protein Affecting 1 (0.4%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Prostate adenocarcinoma projects in all MLH1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate Cancer TCGA obtained from Synapse No 2 1 0.41
The mutations needle plot shows the distribution of the observed MLH1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification